Aggregated Recombinant Human Interferon Beta Induces Antibodies but No Memory in Immune-Tolerant Transgenic Mice

PURPOSE: To study the influence of protein aggregation on the immunogenicity of recombinant human interferon beta (rhIFNβ) in wild-type mice and transgenic, immune-tolerant mice, and to evaluate the induction of immunological memory. METHODS: RhIFNβ-1b and three rhIFNβ-1a preparations with different...

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Bibliografiska uppgifter
Huvudupphovsmän: van Beers, Miranda M. C., Sauerborn, Melody, Gilli, Francesca, Brinks, Vera, Schellekens, Huub, Jiskoot, Wim
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer US 2010
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916121/
https://ncbi.nlm.nih.gov/pubmed/20499141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-010-0172-0
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