Regeneration of the MPTP-Lesioned Dopaminergic System after Convection-Enhanced Delivery of AAV2-GDNF

Clinical studies to date have failed to establish therapeutic benefit of glial cell-derived neurotrophic factor (GDNF) in Parkinson's disease (PD). In contrast to previous nonclinical neuroprotective reports, this study shows clinically relevant and long-lasting regeneration of the dopaminergic...

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Main Authors: Kells, Adrian P., Eberling, Jamie, Su, Xiaomin, Pivirotto, Philip, Bringas, John, Hadaczek, Piotr, Narrow, Wade C., Bowers, William J., Federoff, Howard J., Forsayeth, John, Bankiewicz, Krystof S.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2010
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914692/
https://ncbi.nlm.nih.gov/pubmed/20631185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0942-10.2010
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