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Spectroscopic and Computational Characterization of Substrate-Bound Mouse Cysteine Dioxygenase: Nature of the Ferrous and Ferric Cysteine Adducts and Mechanistic Implications

Cysteine dioxygenase (CDO) is a mononuclear non-heme Fe-dependent dioxygenase that catalyzes the initial step of oxidative cysteine catabolism. Its active site consists of an Fe(II) ion ligated by three histidine residues from the protein, an interesting variation on the more common 2-His-1-carboxyl...

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Detalhes bibliográficos
Main Authors: Gardner, Jessica D., Pierce, Brad S., Fox, Brian G., Brunold, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914100/
https://ncbi.nlm.nih.gov/pubmed/20397631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100189h
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