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Increase in Surface Hydrophobicity of the Cataract-Associated, P23T Mutant of Human GammaD-Crystallin is Responsible for Its Dramatically Lower, Retrograde Solubility

The cataract-associated Pro23 to Thr (P23T) mutation in human γD-crystallin (HGD) has a variety of phenotypes and is geographically widespread. Therefore there is considerable interest in understanding the molecular basis of cataract formation due to this mutation. We showed earlier [Pande, et al. (...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Pande, Ajay, Ghosh, Kalyan S., Banerjee, Priya R., Pande, Jayanti
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2010
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913551/
https://ncbi.nlm.nih.gov/pubmed/20553008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100664s
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