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Increased hydrophobicity and decreased backbone flexibility explain lower solubility of cataract-linked mutant of γD-crystallin
A number of point mutations in γD-crystallin are associated with human cataract. The Pro23Thr (P23T) mutation is perhaps the most common, geographically-widespread, and presents itself in a variety of phenotypes. It is therefore important to understand the molecular basis of lens opacity due to this...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3184788/ https://ncbi.nlm.nih.gov/pubmed/21827768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.07.058 |
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