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NMR study of the cataract-linked P23T mutant of human γD-crystallin shows minor changes in hydrophobic patches that reflect its retrograde solubility
The Pro23 to Thr (P23T) mutation in human γD-crystallin (HGD) shows several cataract phenotypes. We found earlier (Pande et al. (2005) Biochemistry 44, 2491–2500) that the mutation dramatically lowers the solubility of P23T but the overall protein fold is maintained. Recently we observed that soluti...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2707783/ https://ncbi.nlm.nih.gov/pubmed/19275895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.03.007 |
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