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Increase in Surface Hydrophobicity of the Cataract-Associated, P23T Mutant of Human GammaD-Crystallin is Responsible for Its Dramatically Lower, Retrograde Solubility
The cataract-associated Pro23 to Thr (P23T) mutation in human γD-crystallin (HGD) has a variety of phenotypes and is geographically widespread. Therefore there is considerable interest in understanding the molecular basis of cataract formation due to this mutation. We showed earlier [Pande, et al. (...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2913551/ https://ncbi.nlm.nih.gov/pubmed/20553008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100664s |
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