TLR9 Signaling Is Required for Generation of the Adaptive Immune Protection in Cryptococcus neoformans-Infected Lungs

To determine whether TLR9 signaling contributes to the development of the adaptive immune response to cryptococcal infection, wild-type (TLR9+/+) and TLR9 knockout (TLR9−/−) BALB/c mice were infected intratracheally with 10(4) C. neoformans 52D. We evaluated 1) organ microbial burdens, 2) pulmonary...

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Autori principali: Zhang, Yanmei, Wang, Fuyuan, Bhan, Urvashi, Huffnagle, Gary B., Toews, Galen B., Standiford, Theodore J., Olszewski, Michal A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2010
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Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913381/
https://ncbi.nlm.nih.gov/pubmed/20581055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091104
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