Urease Expression by Cryptococcus neoformans Promotes Microvascular Sequestration, Thereby Enhancing Central Nervous System Invasion

Our objective was to determine the role of the cryptococcal virulence factor urease in pulmonary-to-central nervous system, dissemination, invasion, and growth. C. neoformans H99, the urease knockout strain (ure1) derived from H99, and the urease restored strain ure1+URE1−1 were used for thestudies....

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Hlavní autoři: Olszewski, Michal A., Noverr, Mairi C., Chen, Gwo-Hsiao, Toews, Galen B., Cox, Gary M., Perfect, John R., Huffnagle, Gary B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2004
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615675/
https://ncbi.nlm.nih.gov/pubmed/15111322
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