Robust Th1 and Th17 Immunity Supports Pulmonary Clearance but Cannot Prevent Systemic Dissemination of Highly Virulent Cryptococcus neoformans H99

The present study dissected the role of a Th2 bias in pathogenesis of Cryptococcus neoformans H99 infection by comparing inhalational H99 infections in wild-type BALB/c and IL-4/IL-13 double knockout mice. H99-infected wild-type mice showed all major hallmarks of Th2 but not Th1/Th17 immunity in the...

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Detalhes bibliográficos
Main Authors: Zhang, Yanmei, Wang, Fuyuan, Tompkins, Kristin C., McNamara, Andrew, Jain, Aditya V., Moore, Bethany B., Toews, Galen B., Huffnagle, Gary B., Olszewski, Michal A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789623/
https://ncbi.nlm.nih.gov/pubmed/19893050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090530
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