Polymer Partitioning and Ion Selectivity Suggest Asymmetrical Shape for the Membrane Pore Formed by Epsilon Toxin

Using poly-(ethylene glycol)s of different molecular weights, we probe the channels formed in planar lipid bilayers by epsilon toxin secreted by the anaerobic bacterium Clostridium perfringens. We find that the pore is highly asymmetric. The cutoff size of polymers entering the pore through its open...

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Bibliographic Details
Main Authors: Nestorovich, Ekaterina M., Karginov, Vladimir A., Bezrukov, Sergey M.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2010
Subjects:
Channels and Transporters
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913182/
https://ncbi.nlm.nih.gov/pubmed/20682255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.05.014
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