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Polymer Partitioning and Ion Selectivity Suggest Asymmetrical Shape for the Membrane Pore Formed by Epsilon Toxin

Using poly-(ethylene glycol)s of different molecular weights, we probe the channels formed in planar lipid bilayers by epsilon toxin secreted by the anaerobic bacterium Clostridium perfringens. We find that the pore is highly asymmetric. The cutoff size of polymers entering the pore through its open...

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Main Authors: Nestorovich, Ekaterina M., Karginov, Vladimir A., Bezrukov, Sergey M.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913182/
https://ncbi.nlm.nih.gov/pubmed/20682255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.05.014
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