Symmetry Requirements for Effective Blocking of Pore-Forming Toxins: Comparative Study with α-, β-, and γ-Cyclodextrin Derivatives

We compared the abilities of structurally related cationic cyclodextrins to inhibit Bacillus anthracis lethal toxin and Staphylococcus aureus α-hemolysin. We found that both β- and γ-cyclodextrin derivatives effectively inhibited anthrax toxin action by blocking the transmembrane oligomeric pores fo...

Full description

Saved in:
Bibliographic Details
Main Authors: Yannakopoulou, Konstantina, Jicsinszky, Laszlo, Aggelidou, Crysie, Mourtzis, Nikolaos, Robinson, Tanisha M., Yohannes, Adiamseged, Nestorovich, Ekaterina M., Bezrukov, Sergey M., Karginov, Vladimir A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122465/
https://ncbi.nlm.nih.gov/pubmed/21555769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01764-10
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items