Search for Cyclodextrin-Based Inhibitors of Anthrax Toxins: Synthesis, Structural Features, and Relative Activities

Recently, using structure-inspired drug design, we demonstrated that aminoalkyl derivatives of β-cyclodextrin inhibited anthrax lethal toxin action by blocking the transmembrane pore formed by the protective antigen (PA) subunit of the toxin. In the present study, we evaluate a series of new β-cyclo...

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Autores principales: Karginov, Vladimir A., Nestorovich, Ekaterina M., Yohannes, Adiamseged, Robinson, Tanisha M., Fahmi, Nour Eddine, Schmidtmann, Frank, Hecht, Sidney M., Bezrukov, Sergey M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635233/
https://ncbi.nlm.nih.gov/pubmed/16982795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00693-06
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