Cross-species genomics matches driver mutations and cell compartments to model ependymoma

Understanding the biology that underlies histologically similar but molecularly distinct subgroups of cancer has proven difficult since their defining genetic alterations are often numerous, and the cellular origins of most cancers remain unknown1–3. We sought to decipher this heterogeneity by integ...

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Hlavní autoři: Johnson, Robert A., Wright, Karen D., Poppleton, Helen, Mohankumar, Kumarasamypet M., Finkelstein, David, Pounds, Stanley B., Rand, Vikki, Leary, Sarah E.S., White, Elsie, Eden, Christopher, Hogg, Twala, Northcott, Paul, Mack, Stephen, Neale, Geoffrey, Wang, Yong-Dong, Coyle, Beth, Atkinson, Jennifer, DeWire, Mariko, Kranenburg, Tanya A., Gillespie, Yancey, Allen, Jeffrey C., Merchant, Thomas, Boop, Fredrick A., Sanford, Robert. A., Gajjar, Amar, Ellison, David W., Taylor, Michael D., Grundy, Richard G., Gilbertson, Richard J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912966/
https://ncbi.nlm.nih.gov/pubmed/20639864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09173
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