Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

Topoisomerase I (Top1) is a key enzyme acting at the interface between DNA replication, transcription and mRNA maturation. Here, we show that Top1 suppresses genomic instability in mammalian cells by preventing conflicts between transcription and DNA replication. Using DNA combing and ChIP-on-chip,...

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Main Authors: Tuduri, Sandie, Crabbé, Laure, Conti, Chiara, Tourrière, Hélène, Holtgreve-Grez, Heidi, Jauch, Anna, Pantesco, Véronique, De Vos, John, Thomas, Aubin, Theillet, Charles, Pommier, Yves, Tazi, Jamal, Coquelle, Arnaud, Pasero, Philippe
格式: Artigo
語言:Inglês
出版: Macmillan Magazines Ltd 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912930/
https://ncbi.nlm.nih.gov/pubmed/19838172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1984
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