Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

Topoisomerase I (Top1) is a key enzyme acting at the interface between DNA replication, transcription and mRNA maturation. Here, we show that Top1 suppresses genomic instability in mammalian cells by preventing conflicts between transcription and DNA replication. Using DNA combing and ChIP-on-chip,...

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Bibliografische gegevens
Hoofdauteurs: Tuduri, Sandie, Crabbé, Laure, Conti, Chiara, Tourrière, Hélène, Holtgreve-Grez, Heidi, Jauch, Anna, Pantesco, Véronique, De Vos, John, Thomas, Aubin, Theillet, Charles, Pommier, Yves, Tazi, Jamal, Coquelle, Arnaud, Pasero, Philippe
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Macmillan Magazines Ltd 2009
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912930/
https://ncbi.nlm.nih.gov/pubmed/19838172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1984
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