Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

Topoisomerase I (Top1) is a key enzyme acting at the interface between DNA replication, transcription and mRNA maturation. Here, we show that Top1 suppresses genomic instability in mammalian cells by preventing conflicts between transcription and DNA replication. Using DNA combing and ChIP-on-chip,...

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Detalles Bibliográficos
Autores principales: Tuduri, Sandie, Crabbé, Laure, Conti, Chiara, Tourrière, Hélène, Holtgreve-Grez, Heidi, Jauch, Anna, Pantesco, Véronique, De Vos, John, Thomas, Aubin, Theillet, Charles, Pommier, Yves, Tazi, Jamal, Coquelle, Arnaud, Pasero, Philippe
Formato: Artigo
Lenguaje:Inglês
Publicado: Macmillan Magazines Ltd 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912930/
https://ncbi.nlm.nih.gov/pubmed/19838172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1984
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