53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

Germ-line mutations in BRCA1 predispose to breast and ovarian cancer. BRCA1-mutated tumors show genomic instability, mainly as a consequence of impaired recombinatorial DNA repair. Here we identify 53BP1 as an essential factor for sustaining the growth arrest induced by Brca1 deletion. Depletion of...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Bouwman, Peter, Aly, Amal, Escandell, Jose M., Pieterse, Mark, Bartkova, Jirina, van der Gulden, Hanneke, Hiddingh, Sanne, Thanasoula, Maria, Kulkarni, Atul, Yang, Qifeng, Haffty, Bruce G., Tommiska, Johanna, Blomqvist, Carl, Drapkin, Ronny, Adams, David J., Nevanlinna, Heli, Bartek, Jiri, Tarsounas, Madalena, Ganesan, Shridar, Jonkers, Jos
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912507/
https://ncbi.nlm.nih.gov/pubmed/20453858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1831
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares