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Formation of aminyl radicals on electron attachment to AZT: Abstraction from the sugar phosphate backbone vs. one-electron oxidation of Guanine

Employing electron spin resonance (ESR) spectroscopy, we have characterized the radicals formed in 3′-Azido-3′-deoxythymidine (3′-AZT) and in its 5′-analog 5′-azido-5′-deoxythymidine (5′-AZT) after electron attachment in γ-irradiated aqueous (H(2)O or D(2)O) glassy (7.5 M LiCl) systems. ESR spectral...

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Detalhes bibliográficos
Main Authors: Adhikary, Amitava, Khanduri, Deepti, Pottiboyina, Venkata, Rice, Cory T., Sevilla, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912441/
https://ncbi.nlm.nih.gov/pubmed/20575557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp103403p
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