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Using Ligand-Based Virtual Screening to Allosterically Stabilize the Activated State of a GPCR
G-protein coupled receptors (GPCRs) play an essential role in many biological processes. Despite an increase in the number of solved X-ray crystal structures of GPCRs, capturing a GPCR in its activated state for structural analysis has proven to be difficult. An unexplored paradigm is stabilization...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2911999/ https://ncbi.nlm.nih.gov/pubmed/20659113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2009.00944.x |
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