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Modulating G-protein Coupled Receptor/G-protein signal transduction by small molecules suggested by virtual screening

Modulation of interactions between activated GPCRs (G-protein coupled receptors) and the intracellular (IC) signal transducers, heterotrimeric G-proteins, is an attractive, yet essentially unexplored, paradigm for treatment of certain diseases. Regulating downstream signaling for treatment of congen...

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Главные авторы: Taylor, Christina M., Barda, Yaniv, Kisselev, Oleg G., Marshall, Garland R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664537/
https://ncbi.nlm.nih.gov/pubmed/18707087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800326q
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