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Modulating G-protein Coupled Receptor/G-protein signal transduction by small molecules suggested by virtual screening
Modulation of interactions between activated GPCRs (G-protein coupled receptors) and the intracellular (IC) signal transducers, heterotrimeric G-proteins, is an attractive, yet essentially unexplored, paradigm for treatment of certain diseases. Regulating downstream signaling for treatment of congen...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2664537/ https://ncbi.nlm.nih.gov/pubmed/18707087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800326q |
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