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Stabilizers of the Max Homodimer Identified in Virtual Ligand Screening Inhibit Myc Function
Many human cancers show constitutive or amplified expression of the transcriptional regulator and oncoprotein Myc, making Myc a potential target for therapeutic intervention. Here we report the down-regulation of Myc activity by reducing the availability of Max, the essential dimerization partner of...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Pharmacology and Experimental Therapeutics
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2730382/ https://ncbi.nlm.nih.gov/pubmed/19498040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.054858 |
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