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Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts

Myc is a transcriptional regulator of the basic helix–loop–helix leucine zipper protein family. It has strong oncogenic potential, mutated or virally transduced forms of Myc induce lymphoid tumors in animals, and deregulated expression of Myc is associated with numerous types of human cancers. For i...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Berg, Thorsten, Cohen, Steven B., Desharnais, Joel, Sonderegger, Corinna, Maslyar, Daniel J., Goldberg, Joel, Boger, Dale L., Vogt, Peter K.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122609/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11891322/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.062036999
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