Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis

INTRODUCTION: Type 4 phosphodiesterases (PDE4) play an important role in immune cells through the hydrolysis of the second messenger, cAMP. Inhibition of PDE4 has previously been shown to suppress immune and inflammatory responses, demonstrating PDE4 to be a valid therapeutic target for immune-media...

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Bibliografske podrobnosti
Main Authors: McCann, Fiona E, Palfreeman, Andrew C, Andrews, Melanie, Perocheau, Dany P, Inglis, Julia J, Schafer, Peter, Feldmann, Marc, Williams, Richard O, Brennan, Fionula M
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911898/
https://ncbi.nlm.nih.gov/pubmed/20525198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3041
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