Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells

Increasing evidence suggests that regulatory T cell (Treg) function is impaired in chronic inflammatory diseases such as rheumatoid arthritis (RA). Here we demonstrate that Tregs are unable to modulate the spontaneous production of TNF-α from RA synovial cells cultured from the diseased synovium sit...

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Detalhes bibliográficos
Main Authors: Beavis, Paul A., Gregory, Bernard, Green, Patricia, Cribbs, Adam P., Kennedy, Alan, Amjadi, Parisa, Palfreeman, Andrew C., Feldmann, Marc, Brennan, Fionula M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189031/
https://ncbi.nlm.nih.gov/pubmed/21926327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112722108
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