Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis

INTRODUCTION: Type 4 phosphodiesterases (PDE4) play an important role in immune cells through the hydrolysis of the second messenger, cAMP. Inhibition of PDE4 has previously been shown to suppress immune and inflammatory responses, demonstrating PDE4 to be a valid therapeutic target for immune-media...

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Autors principals: McCann, Fiona E, Palfreeman, Andrew C, Andrews, Melanie, Perocheau, Dany P, Inglis, Julia J, Schafer, Peter, Feldmann, Marc, Williams, Richard O, Brennan, Fionula M
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911898/
https://ncbi.nlm.nih.gov/pubmed/20525198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3041
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