Identification of Chemical Compounds that Induce HIF-1α Activity

Cellular metabolism depends on the availability of oxygen and the major regulator of oxygen homeostasis is hypoxia-inducible factor 1 (HIF-1), a highly conserved transcription factor that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF-1 is a heterodimeric tran...

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Detalles Bibliográficos
Autores principales: Xia, Menghang, Huang, Ruili, Sun, Yi, Semenza, Gregg L., Aldred, Shelley Force, Witt, Kristine L., Inglese, James, Tice, Raymond R., Austin, Christopher P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2009
Materias:
IN VITRO Toxicology and Alternative Testing
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910898/
https://ncbi.nlm.nih.gov/pubmed/19502547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp123
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