Identification of small molecule compounds that inhibit the HIF-1 signaling pathway

BACKGROUND: Hypoxia-inducible factor-1 (HIF-1) is the major hypoxia-regulated transcription factor that regulates cellular responses to low oxygen environments. HIF-1 is composed of two subunits: hypoxia-inducible HIF-1α and constitutively-expressed HIF-1β. During hypoxic conditions, HIF-1α heterodi...

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Detalhes bibliográficos
Principais autores: Xia, Menghang, Bi, Kun, Huang, Ruili, Cho, Ming-Hsuang, Sakamuru, Srilatha, Miller, Susanne C, Li, Hua, Sun, Yi, Printen, John, Austin, Christopher P, Inglese, James
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797767/
https://ncbi.nlm.nih.gov/pubmed/20003191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-8-117
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