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Identification of small molecule compounds that inhibit the HIF-1 signaling pathway
BACKGROUND: Hypoxia-inducible factor-1 (HIF-1) is the major hypoxia-regulated transcription factor that regulates cellular responses to low oxygen environments. HIF-1 is composed of two subunits: hypoxia-inducible HIF-1α and constitutively-expressed HIF-1β. During hypoxic conditions, HIF-1α heterodi...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2797767/ https://ncbi.nlm.nih.gov/pubmed/20003191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-8-117 |
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