Weighted Feature Significance: A Simple, Interpretable Model of Compound Toxicity Based on the Statistical Enrichment of Structural Features

In support of the U.S. Tox21 program, we have developed a simple and chemically intuitive model we call weighted feature significance (WFS) to predict the toxicological activity of compounds, based on the statistical enrichment of structural features in toxic compounds. We trained and tested the mod...

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Detalhes bibliográficos
Main Authors: Huang, Ruili, Southall, Noel, Xia, Menghang, Cho, Ming-Hsuang, Jadhav, Ajit, Nguyen, Dac-Trung, Inglese, James, Tice, Raymond R., Austin, Christopher P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
IN VITRO Toxicology and Alternative Testing
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777082/
https://ncbi.nlm.nih.gov/pubmed/19805409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp231
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