Weighted Feature Significance: A Simple, Interpretable Model of Compound Toxicity Based on the Statistical Enrichment of Structural Features

In support of the U.S. Tox21 program, we have developed a simple and chemically intuitive model we call weighted feature significance (WFS) to predict the toxicological activity of compounds, based on the statistical enrichment of structural features in toxic compounds. We trained and tested the mod...

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Hlavní autoři: Huang, Ruili, Southall, Noel, Xia, Menghang, Cho, Ming-Hsuang, Jadhav, Ajit, Nguyen, Dac-Trung, Inglese, James, Tice, Raymond R., Austin, Christopher P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
IN VITRO Toxicology and Alternative Testing
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777082/
https://ncbi.nlm.nih.gov/pubmed/19805409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp231
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