Weighted Feature Significance: A Simple, Interpretable Model of Compound Toxicity Based on the Statistical Enrichment of Structural Features

In support of the U.S. Tox21 program, we have developed a simple and chemically intuitive model we call weighted feature significance (WFS) to predict the toxicological activity of compounds, based on the statistical enrichment of structural features in toxic compounds. We trained and tested the mod...

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Bibliographic Details
Main Authors: Huang, Ruili, Southall, Noel, Xia, Menghang, Cho, Ming-Hsuang, Jadhav, Ajit, Nguyen, Dac-Trung, Inglese, James, Tice, Raymond R., Austin, Christopher P.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
IN VITRO Toxicology and Alternative Testing
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777082/
https://ncbi.nlm.nih.gov/pubmed/19805409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp231
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