Weighted Feature Significance: A Simple, Interpretable Model of Compound Toxicity Based on the Statistical Enrichment of Structural Features

In support of the U.S. Tox21 program, we have developed a simple and chemically intuitive model we call weighted feature significance (WFS) to predict the toxicological activity of compounds, based on the statistical enrichment of structural features in toxic compounds. We trained and tested the mod...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Huang, Ruili, Southall, Noel, Xia, Menghang, Cho, Ming-Hsuang, Jadhav, Ajit, Nguyen, Dac-Trung, Inglese, James, Tice, Raymond R., Austin, Christopher P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2009
Pynciau:
IN VITRO Toxicology and Alternative Testing
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777082/
https://ncbi.nlm.nih.gov/pubmed/19805409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp231
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