Ubiquitin Proteasome Pathway–Mediated Degradation of Proteins: Effects Due to Site-Specific Substrate Deamidation

PURPOSE. The accumulation, aggregation, and precipitation of proteins is etiologic for age-related diseases, particularly cataract, because the precipitates cloud the lens. Deamidation of crystallins is associated with protein precipitation, aging, and cataract. Among the roles of the ubiquitin prot...

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Bibliografiska uppgifter
Huvudupphovsmän: Dudek, Edward J., Lampi, Kirsten J., Lampi, Jason A., Shang, Fu, King, Jonathan, Wang, Yongting, Taylor, Allen
Materialtyp: Artigo
Språk:Inglês
Publicerad: Association for Research in Vision and Ophthalmology, Inc. 2010
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910644/
https://ncbi.nlm.nih.gov/pubmed/20592226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.09-4087
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