Degradation of C-terminal Truncated αA-crystallins by the Ubiquitin–Proteasome Pathway

PURPOSE: Calpain-mediated C-terminal cleavage of αA-crystallins occurs during aging and cataractogenesis. The objective of the present study was to explore the role of the ubiquitin-proteasome pathway (UPP) in degrading C-terminal truncated αA-crystallins. METHODS: Recombinant wild-type (wt) αA-crys...

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Main Authors: Zhang, Xinyu, Dudek, Edward J., Liu, Bingfen, Ding, Linlin, Fernandes, Alexandre F., Liang, Jack J., Horwitz, Joseph, Taylor, Allen, Shang, Fu
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2098745/
https://ncbi.nlm.nih.gov/pubmed/17724207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.07-0196
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