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Oligomerization with wt αA- and αB-Crystallins Reduces Proteasome-Mediated Degradation of C-Terminally Truncated αA-Crystallin

PURPOSE. We previously demonstrated that the ubiquitin-proteasome pathway (UPP) is a general protein quality control system that selectively degrades damaged or abnormal lens proteins, including C-terminally truncated αA-crystallin. The objective of this work was to determine the effects of wt αA- a...

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Detalhes bibliográficos
Main Authors: Wu, Mingxing, Zhang, Xinyu, Bian, Qingning, Taylor, Allen, Liang, Jack J., Ding, Linlin, Horwitz, Joseph, Shang, Fu
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358126/
https://ncbi.nlm.nih.gov/pubmed/22427585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-9147
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