The C-terminal α–α superhelix of Pat is required for mRNA decapping in metazoa

Pat proteins regulate the transition of mRNAs from a state that is translationally active to one that is repressed, committing targeted mRNAs to degradation. Pat proteins contain a conserved N-terminal sequence, a proline-rich region, a Mid domain and a C-terminal domain (Pat-C). We show that Pat-C...

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Main Authors: Braun, Joerg E, Tritschler, Felix, Haas, Gabrielle, Igreja, Cátia, Truffault, Vincent, Weichenrieder, Oliver, Izaurralde, Elisa
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910274/
https://ncbi.nlm.nih.gov/pubmed/20543818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.124
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