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The Fanconi anemia pathway promotes replication-dependent DNA interstrand crosslink repair

Fanconi anemia is a human cancer predisposition syndrome caused by mutations in thirteen Fanc genes. The disorder is characterized by genomic instability and cellular hypersensitivity to chemicals that generate DNA interstrand crosslinks (ICLs). A central event in the activation of the Fanconi anemi...

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Bibliografske podrobnosti
Main Authors: Knipscheer, Puck, Räschle, Markus, Smogorzewska, Agata, Enoiu, Milica, Ho, The Vinh, Schärer, Orlando D., Elledge, Stephen J., Walter, Johannes C.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909596/
https://ncbi.nlm.nih.gov/pubmed/19965384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1182372
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