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The Fanconi anemia pathway promotes replication-dependent DNA interstrand crosslink repair
Fanconi anemia is a human cancer predisposition syndrome caused by mutations in thirteen Fanc genes. The disorder is characterized by genomic instability and cellular hypersensitivity to chemicals that generate DNA interstrand crosslinks (ICLs). A central event in the activation of the Fanconi anemi...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2909596/ https://ncbi.nlm.nih.gov/pubmed/19965384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1182372 |
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