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Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature-aging syndrome caused by a dominant mutation in the gene encoding lamin A, which leads to an aberrantly spliced and processed protein termed progerin. Previous studies have shown that progerin induces early senescence associated with increas...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Company of Biologists
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2908049/ https://ncbi.nlm.nih.gov/pubmed/20605919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.067306 |
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