Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

Hutchinson-Gilford progeria syndrome (HGPS), a devastating premature aging disease, is caused by a point mutation in the lamin A gene (LMNA). This mutation constitutively activates a cryptic splice donor site, resulting in a mutant lamin A protein known as progerin. Recent studies have demonstrated...

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Bibliographische Detailangaben
Hauptverfasser: Cao, Kan, Blair, Cecilia D., Faddah, Dina A., Kieckhaefer, Julia E., Olive, Michelle, Erdos, Michael R., Nabel, Elizabeth G., Collins, Francis S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223819/
https://ncbi.nlm.nih.gov/pubmed/21670498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43578
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