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Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts
Hutchinson-Gilford progeria syndrome (HGPS), a devastating premature aging disease, is caused by a point mutation in the lamin A gene (LMNA). This mutation constitutively activates a cryptic splice donor site, resulting in a mutant lamin A protein known as progerin. Recent studies have demonstrated...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3223819/ https://ncbi.nlm.nih.gov/pubmed/21670498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43578 |
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