MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence

Protection of telomere 1 (POT1), the telomeric single-stranded DNA (ssDNA)-binding protein in the shelterin complex, has been implicated in the DNA damage response, tumorigenesis and aging. Telomere dysfunction induced by telomere deprotection could accelerate cellular senescence in primary human ce...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Aging (Albany NY)
Egile Nagusiak: Li, Tingting, Luo, Zhenhua, Lin, Song, Li, Chujun, Dai, Shenkun, Wang, Haoli, Huang, Junjiu, Ma, Wenbin, Songyang, Zhou, Huang, Yan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals 2020
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425516/
https://ncbi.nlm.nih.gov/pubmed/32687062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103541
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