MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence

Protection of telomere 1 (POT1), the telomeric single-stranded DNA (ssDNA)-binding protein in the shelterin complex, has been implicated in the DNA damage response, tumorigenesis and aging. Telomere dysfunction induced by telomere deprotection could accelerate cellular senescence in primary human ce...

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Dades bibliogràfiques
Publicat a:Aging (Albany NY)
Autors principals: Li, Tingting, Luo, Zhenhua, Lin, Song, Li, Chujun, Dai, Shenkun, Wang, Haoli, Huang, Junjiu, Ma, Wenbin, Songyang, Zhou, Huang, Yan
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals 2020
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425516/
https://ncbi.nlm.nih.gov/pubmed/32687062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103541
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