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Paradoxical suppression of cellular senescence by p53

The tumor suppressor p53 is a canonical inducer of cellular senescence (irreversible loss of proliferative potential and senescent morphology). p53 can also cause reversible arrest without senescent morphology, which has usually been interpreted as failure of p53 to induce senescence. Here we demons...

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Autors principals: Demidenko, Zoya N., Korotchkina, Lioubov G., Gudkov, Andrei V., Blagosklonny, Mikhail V.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906905/
https://ncbi.nlm.nih.gov/pubmed/20457898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002298107
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