Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program)

In proliferating cells, mTOR is active and promotes cell growth. When the cell cycle is arrested, then mTOR converts reversible arrest to senescence (geroconversion). Rapamycin and other rapalogs suppress geroconversion, maintaining quiescence instead. Here we showed that ATP-competitive kinase inhi...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Leontieva, Olga V., Demidenko, Zoya N., Blagosklonny, Mikhail V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2015
Konular:
Research Paper: Pathology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695114/
https://ncbi.nlm.nih.gov/pubmed/26177051
Etiketler: Etiketle
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