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Phosphorylation of PPP(S/T)P Motif of the Free LRP6 Intracellular Domain Is Not Required to Activate the Wnt/β-Catenin Pathway and Attenuate GSK3β Activity
The canonical Wnt/β-catenin signaling pathway plays a critical role in numerous physiological and pathological processes. LRP6 is an essential co-receptor for Wnt/β-catenin signaling; as transduction of the Wnt signal is strongly dependent upon GSK3β-mediated phosphorylation of multiple PPP(S/T)P mo...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2906752/ https://ncbi.nlm.nih.gov/pubmed/19711366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22318 |
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