Mitogen-Activated Protein Kinases Promote WNT/β-Catenin Signaling via Phosphorylation of LRP6

LDL-related protein 6 (LRP6) is a coreceptor of WNTs and a key regulator of the WNT/β-catenin pathway. Upon activation, LRP6 is phosphorylated within its intracellular PPPS/TP motifs. These phosphorylated motifs are required to recruit axin and to inhibit glycogen synthase kinase 3 (GSK3), two basic...

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Autori principali: Červenka, Igor, Wolf, Joshua, Mašek, Jan, Krejci, Pavel, Wilcox, William R., Kozubík, Alois, Schulte, Gunnar, Gutkind, J. Silvio, Bryja, Vítězslav
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019858/
https://ncbi.nlm.nih.gov/pubmed/20974802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00550-10
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