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Targeted delivery of NRAS(Q61R) and Cre-recombinase to postnatal melanocytes induces melanoma in Ink4a/Arf(lox/lox) mice
We have developed a somatic cell gene delivery mouse model of melanoma that allows for the rapid validation of genetic alterations identified in this disease. A major advantage of this system is the ability to model the multi-step process of carcinogenesis in immune-competent mice without the genera...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2906690/ https://ncbi.nlm.nih.gov/pubmed/20444198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1755-148X.2010.00717.x |
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