Destabilization of the A1 Domain in von Willebrand Factor Dissociates the A1A2A3 Tri-domain and Provokes Spontaneous Binding to Glycoprotein Ibα and Platelet Activation under Shear Stress

This study used recombinant A1A2A3 tri-domain proteins to demonstrate that A domain association in von Willebrand factor (VWF) regulates the binding to platelet glycoprotein Ibα (GPIbα). We performed comparative studies between wild type (WT) A1 domain and the R1450E variant that dissociates the tri...

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Main Authors: Auton, Matthew, Sowa, Katie E., Smith, Scott M., Sedlák, Erik, Vijayan, K. Vinod, Cruz, Miguel A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906274/
https://ncbi.nlm.nih.gov/pubmed/20498367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.103358
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