N-terminal Flanking Region of A1 Domain in von Willebrand Factor Stabilizes Structure of A1A2A3 Complex and Modulates Platelet Activation under Shear Stress

von Willebrand factor (vWF) mediates platelet adhesion and thrombus formation via its interaction with the platelet receptor glycoprotein (GP)Ibα. We have analyzed two A1A2A3 tri-domain proteins to demonstrate that the amino acid sequence, Gln(1238)-Glu(1260), in the N-terminal flanking region of th...

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Bibliographic Details
Main Authors: Auton, Matthew, Sowa, Katie E., Behymer, Molly, Cruz, Miguel A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340263/
https://ncbi.nlm.nih.gov/pubmed/22431729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.348573
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